Selank
Also known as TP-7, Tuftsin analog
Selank is a synthetic analog of the immunomodulatory tetrapeptide tuftsin, studied in behavioral and neurochemistry research. A research-use profile: sequence, tuftsin lineage, and handling.
Selank belongs to a small family of Russian-developed regulatory peptides, and the single most useful thing to know about it is its parentage: it is a synthetic analog of tuftsin, a four-residue fragment (Thr-Lys-Pro-Arg) that occurs naturally as part of an immunoglobulin heavy chain and has long been characterized in immunology as an immunomodulator.
Where tuftsin is short-lived, Selank appends a Pro-Gly-Pro tail. That proline-flanked extension is not decorative — proline-rich termini are a recurring trick in peptide chemistry for slowing enzymatic breakdown, and it is the reason Selank is studied as a distinct molecule rather than as tuftsin under another name.
This page stays with what is verifiable — the sequence, the tuftsin relationship, and the research areas the compound appears in — and does not venture into outcomes or dosing.
Selank is a synthetic heptapeptide built around tuftsin — the naturally occurring immunomodulatory tetrapeptide Thr-Lys-Pro-Arg — extended at the C-terminus with a Pro-Gly-Pro stabilizing motif. The added tripeptide is the design feature that distinguishes it from tuftsin itself.
The tuftsin connection
Tuftsin is a well-characterized tetrapeptide with a documented role in immune signaling; it is the biological anchor for Selank's design. By retaining the intact Thr-Lys-Pro-Arg core and grafting a Pro-Gly-Pro segment onto it, chemists produced a molecule that keeps the recognizable tuftsin motif while behaving differently in solution.
This heritage is why Selank is often discussed at the intersection of immunopeptide research and neuropeptide research, rather than sitting cleanly in one field. The two literatures overlap in the tuftsin story.
Research contexts
In the published literature, Selank appears most often in behavioral neuroscience and neurochemistry models — work examining anxiety-related behavior paradigms and monoamine and peptide signaling in animal studies. These describe the settings in which the peptide has been investigated; they are not effects offered to anyone.
It is frequently mentioned alongside Semax, another Russian regulatory peptide, because the two share a research lineage and are often studied by overlapping groups — though they derive from entirely different parent molecules.
Reading a Selank certificate of analysis
Because Selank is a defined seven-residue sequence, a mass-spectrometry trace should correspond to a heptapeptide and an HPLC trace should resolve to a dominant single peak. Confirm that the reported sequence retains the Thr-Lys-Pro-Arg tuftsin core followed by Pro-Gly-Pro, and that the lot carries a batch identifier tied to its own certificate.
These are research areas the compound is associated with in the literature — not medical claims or intended uses.
Handling & storage
Supplied lyophilized. Stored sealed and cold; in research settings it is reconstituted with bacteriostatic water only when a protocol requires it, then kept refrigerated. Handle per accepted laboratory practice.
Verify a certificate by lot →Common questions
It is a synthetic analog of tuftsin, a naturally occurring immunomodulatory tetrapeptide (Thr-Lys-Pro-Arg). Selank keeps that core and adds a Pro-Gly-Pro tail.
Seven amino acids (a heptapeptide): the four-residue tuftsin core followed by a Pro-Gly-Pro stabilizing extension.
They share a Russian regulatory-peptide research lineage but come from different parents — Selank from tuftsin, Semax from a fragment of ACTH. They are structurally unrelated.
This monograph is a research-use reference. It describes composition and the contexts in which the compound has been studied — it is not medical advice, a description of effects, or a recommendation for use. Sold strictly for laboratory and research use; not for human or animal consumption.