Epitalon
Also known as Epithalon, Epithalone, AEDG peptide, Ala-Glu-Asp-Gly
Epitalon (AEDG) is a synthetic four-residue peptide from the Russian bioregulator tradition, studied in aging and telomere biology research. A research-use profile: sequence, lineage, and handling.
Epitalon is unusually short for a peptide that carries so much history. Just four amino acids — alanine, glutamate, aspartate, glycine — it emerged from a Soviet-era line of research on the pineal gland and its peptide fractions, associated most closely with the work of Vladimir Khavinson.
That lineage is the interesting part, and it is also where most write-ups go wrong: they leap from 'derived from a pineal preparation' to promises about lifespan. This page stays on the verifiable ground — what the molecule is, where it sits in the research literature, and how a lab handles it — and treats the telomere and aging discussion strictly as a research context rather than an outcome.
A short, fully synthetic tetrapeptide. Its sequence was derived as a proposed active motif of epithalamin, a peptide preparation historically obtained from the pineal gland. Because the chain is only four residues long, it is one of the simplest peptides in the so-called bioregulator literature.
The bioregulator lineage
Epitalon belongs to a family of very short synthetic peptides that Russian researchers termed 'peptide bioregulators.' The idea behind the program was that specific short sequences, abstracted from tissue extracts, might be studied as signaling motifs. Epitalon was proposed as a synthetic counterpart to epithalamin, a pineal-derived preparation.
Understanding this context matters because it explains why epitalon is almost always discussed alongside other members of the same family — pinealon and cartalax among them — which share the design philosophy of a minimal, defined sequence rather than a large protein.
Where it appears in the literature
In published work, epitalon is studied most often in the context of aging research and, specifically, telomere biology — including questions about telomerase activity in cultured cells. These are the areas scientists have examined it in; naming them describes a research context, not a promised effect.
It is a frequent reference point in gerontology-adjacent peptide discussions, which is why it anchors the 'longevity' cluster in most catalogs.
Reading an epitalon certificate of analysis
A four-residue peptide is about as easy as it gets to characterize. A mass-spectrometry trace should agree with a very small, well-defined mass, and an HPLC trace should resolve to a dominant single peak. Because the sequence is so short, there is little room for a certificate to hide behind vagueness — look for the method and a batch identifier, not just a headline purity figure. Every lot we list is tied to its own certificate.
These are research areas the compound is associated with in the literature — not medical claims or intended uses.
Handling & storage
Supplied lyophilized. Kept sealed and cold; in research settings it is reconstituted with bacteriostatic water only when a protocol calls for it, then refrigerated. Handle per accepted laboratory practice.
Verify a certificate by lot →Common questions
Epitalon and Epithalon are two spellings of the same synthetic tetrapeptide (AEDG). Epithalamin refers to the older pineal-derived peptide preparation that inspired the synthetic sequence — related in lineage, but not identical.
Four amino acids: alanine, glutamate, aspartate, glycine (Ala-Glu-Asp-Gly). It is one of the shortest peptides commonly listed in the bioregulator literature.
All three come from the same Russian 'peptide bioregulator' research tradition of short, defined synthetic sequences. They are grouped by shared design and lineage, though each has been studied with a different tissue emphasis.
This monograph is a research-use reference. It describes composition and the contexts in which the compound has been studied — it is not medical advice, a description of effects, or a recommendation for use. Sold strictly for laboratory and research use; not for human or animal consumption.