Larazotide
Also known as Larazotide acetate, AT-1001, INN-202
Larazotide is a synthetic octapeptide studied in the context of intestinal tight junctions and the zonulin pathway. A research-use profile: its barrier-regulation angle and handling.
Larazotide belongs to a corner of peptide research that most of this catalog doesn't touch: the biology of the gaps between cells. Epithelial sheets — the lining of the gut, for instance — are stitched together by tight junctions, and the permeability of that barrier is a regulated, dynamic thing. Larazotide is studied squarely in the context of that regulation.
The profile below is deliberately narrow and verifiable: its identity as a synthetic octapeptide, the tight-junction and zonulin research angle it is associated with, and how it is handled. It makes no claims about outcomes.
Larazotide is a synthetic eight-residue peptide (an octapeptide), commonly handled as the acetate salt. Its research identity centers on the intestinal tight-junction and zonulin pathway rather than on receptor agonism. The sequence is described here as a defined octapeptide rather than enumerated residue-by-residue.
The tight-junction and zonulin angle
Tight junctions are the protein complexes that seal the space between adjacent epithelial cells and set how permeable a barrier is. Their assembly and disassembly are actively regulated, and one signaling axis associated with that regulation involves zonulin, a modulator implicated in loosening tight-junction integrity.
Larazotide is discussed in the research literature specifically in relation to this barrier-permeability biology — it is studied as a peptide acting at the tight-junction / zonulin level rather than as a hormone or growth-factor analog. That barrier-regulation framing is what distinguishes it from nearly every other peptide in this catalog and is the reason it is grouped with gut-lining research contexts.
A defined synthetic octapeptide
Larazotide is a synthetic peptide of eight amino acids, most often supplied and referenced as the acetate salt (larazotide acetate). Its development codes — AT-1001 and INN-202 — are the identifiers under which much of the research literature files it, so they are useful search terms when tracking down primary sources.
As a short, defined sequence it is straightforward to characterize in principle: a certificate of analysis should tie its mass and a dominant chromatographic peak to the intended octapeptide and to a batch identifier. Every lot we list is tied to its own certificate — verify yours by its batch number.
These are research areas the compound is associated with in the literature — not medical claims or intended uses.
Handling & storage
Supplied lyophilized, commonly as the acetate salt. Stored sealed and cold; reconstituted with bacteriostatic water only when a protocol requires it, then kept refrigerated. Handle per accepted laboratory practice.
Verify a certificate by lot →Common questions
It is a synthetic octapeptide — a chain of eight amino acids — usually handled as the acetate salt (larazotide acetate).
Tight junctions are the protein seals between epithelial cells that govern barrier permeability. Larazotide is studied in the research context of that tight-junction biology and the related zonulin pathway.
They are development-code names for larazotide. Much of the primary research literature files the peptide under these identifiers, so they are helpful when searching for source material.
This monograph is a research-use reference. It describes composition and the contexts in which the compound has been studied — it is not medical advice, a description of effects, or a recommendation for use. Sold strictly for laboratory and research use; not for human or animal consumption.